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Abstract Nanophotonic freeform design has the potential to push the performance of optical components to new limits, but there remains a challenge to effectively perform optimization while reliably enforcing design and manufacturing constraints. We present Neuroshaper, a framework for freeform geometric parameterization in which nanophotonic device layouts are defined using an analytic neural network representation. Neuroshaper serves as a qualitatively new way to perform shape optimization by capturing multi-scalar, freeform geometries in an overparameterized representation scheme, enabling effective optimization in a smoothened, high dimensional geometric design space. We show that Neuroshaper can enforce constraints and topology manipulation in a manner where local constraints lead to global changes in device morphology. We further show numerically and experimentally that Neuroshaper can apply to a diversity of nanophotonic devices. The versatility and capabilities of Neuroshaper reflect the ability of neural representation to augment concepts in topological design. 

Over the past decade, deep reinforcement learning (RL) techniques have significantly advanced robotic systems. However, due to the complex architectures of neural network models, ensuring their trustworthiness is a considerable challenge. Programmatic reinforcement learning has surfaced as a promising approach. Nonetheless, synthesizing robot-control programs remains challenging. Existing methods rely on domain-specific languages (DSLs) populated with user-defined state abstraction predicates and a library of low-level controllers as abstract actions to boot synthesis, which is impractical in unknown environments that lack such predefined components. To address this limitation, we introduce RoboScribe, a novel abstraction refinement-guided program synthesis framework that automatically derives robot state and action abstractions from raw, unsegmented task demonstrations in high-dimensional, continuous spaces. It iteratively enriches and refines an initially coarse abstraction until it generates a task-solving program over the abstracted robot environment. RoboScribe is effective in synthesizing iterative programs by inferring recurring subroutines directly from the robot’s raw, continuous state and action spaces, without needing predefined abstractions. Experimental results show that RoboScribe programs inductively generalize to long-horizon robot tasks involving arbitrary numbers of objects, outperforming baseline methods in terms of both interpretability and efficiency. 

DNA methylation, a covalent modification, fundamentally shapes mammalian gene regulation and cellular identity. This review examines methylation's biochemical underpinnings, genomic distribution patterns, and analytical approaches. We highlight three distinctive aspects that separate methylation from other epigenetic marks: its remarkable stability as a silencing mechanism, its capacity to maintain distinct states independently of DNA sequence, and its effectiveness as a quantitative trait linking genotype to disease risk. We also explore the phenomenon of methylation clocks and their biological significance. The review addresses technical considerations across major assay types—both array-based technologies and sequencing approaches—with emphasis on data normalization, quality control, cell proportion inference, and the specialized statistical models required for next-generation sequencing analysis. 

Vehicle-to-everything (V2X) collaborative perception has emerged as a promising solution to address the limitations of single-vehicle perception systems. However, existing V2X datasets are limited in scope, diversity, and quality. To address these gaps, we present Mixed Signals, a comprehensive V2X dataset featuring 45.1k point clouds and 240.6k bounding boxes collected from three connected autonomous vehicles (CAVs) equipped with two different configurations of LiDAR sensors, plus a roadside unit with dual LiDARs. Our dataset provides point clouds and bounding box annotations across 10 classes, ensuring reliable data for perception training. We provide detailed statistical analysis on the quality of our dataset and extensively benchmark existing V2X methods on it. Mixed Signals is ready-to-use, with precise alignment and consistent annotations across time and viewpoints. We hope our work advances research in the emerging, impactful field of V2X perception. Dataset details at https://mixedsignalsdataset.cs.cornell.edu/.